GATA-6 Activates Transcription of Thyroid Transcription Factor-1

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Thyroid transcription factor-1 (TTF1)

 A strong, distinct nuclear staining reaction of type II pneumocytes, Clara cells and basal cells of the terminal bronchioles in the lung.  A moderate to strong, distinct nuclear staining reaction of the columnar epithelial cells of the terminal bronchioles in the lung.  A strong, distinct nuclear staining reaction of all follicular epithelial cells in the thyroid gland.  A strong nuclear s...

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The transcription factor GATA-6 regulates pathological cardiac hypertrophy.

RATIONALE The transcriptional code that programs maladaptive cardiac hypertrophy involves the zinc finger-containing DNA binding factor GATA-4. The highly related transcription factor GATA-6 is also expressed in the adult heart, although its role in controlling the hypertrophic program is unknown. OBJECTIVE To determine the role of GATA-6 in cardiac hypertrophy and homeostasis. METHODS AND ...

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The GATA-1 transcription factor is capable of suppressing the myeloid gene expression program when ectopically expressed in myeloid cells. We examined the ability of GATA-1 to repress the expression and function of the PU.1 transcription factor, a central regulator of myeloid differentiation. We found that GATA-1 is capable of suppressing the myeloid phenotype without interfering with PU.1 gene...

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Thyroid transcription factor 1 in pulmonary adenocarcinoma.

AIMS To discover whether variations in thyroid transcription factor 1 (TTF-1) staining in different subtypes and patterns of pulmonary adenocarcinoma are related to the putative origin of the tumour. In addition, to confirm the specificity of TTF-1 for pulmonary (as opposed to other sites) adenocarcinoma, to examine the possible prognostic relevance of TTF-1 positivity in lung cancer, and to re...

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Surfactant protein C (SP-C; Sftpc) gene expression is restricted to pulmonary type II epithelial cells. The proximal SP-C promoter region contains critical binding sites for nuclear factor I (NFI) and thyroid transcription factor 1 (TTF-1; also called Nkx2.1). To test the hypothesis that NFI isoforms interact with TTF-1 to differentially regulate SP-C transcription, we performed transient trans...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1999

ISSN: 0021-9258

DOI: 10.1074/jbc.274.5.2658